The City & The City (China Miéville) and Palimpsest (Catherynne M. Valente): I just can't get into these books. It's not that they are bad, it's just that I'm not finding them that interesting. I suspect that I'm not the target audience for Palimpest, and The City is putting me to sleep.
The Windup Girl (Paolo Bacigalupi): Paolo paints a very interesting world, but I'm a third of the way into it and haven't found any character to really root for. I think this is the story of Emiko, the "New Person" / genetically-made sex slave. If so, frankly, Charlie Stross did it better with Saturn's Children. Most of the rest of the characters aren't really grabbing me. I do have a nit to pick with Paolo: in his post-oil world, everything is powered by springs and compressed gases. This includes guns, despite the fact that gunpowder was invented well before the Industrial Revolution.
Julian Comstock: A Story of 22nd-Century America (Robert Charles Wilson): I found this a very entertaining story. It's at first blush a straight-forward actioner, but at the end turns to an attempt to tell the story of imperial collapse from Nero's point of view. Neat twists.
Wake (Robert J. Sawyer): I'm about a third of the way into this one, and really enjoying it. Sawyer has some very interesting concepts about consciousness and intelligence. Ranking this against Comstock will be a tough decision.
Boneshaker (Cherie Priest): This is still, I think, the strongest candidate on the ballot.
Well, I think you're looking at my novel picks, more or less in order from "no vote" to "number one," although Wake and Comstock might swap spots.